1.1 This guide outlines sustainability factors for product manufacturers to consider when comparing alternative chemicals or ingredients across the life cycle of a product. Such an analysis could be used in product development, answering customer inquiries, or replying to regulatory requests, among others. 1.2 This guide integrates many of the principles of green chemistry and green engineering in evaluating the factors across the social (including human health), economic, and ecological attributes in the use of a particular material and potential alternatives in a particular product. 1.3 This guide provides an outline for the contents of a report of the results of the analysis, including an executive summary, detailed report, and retrospective. 1.4 This guide does not provide guidance on how to perform chemical risk assessment, alternatives assessment, life-cycle assessment, or economic analysis, or how the alternatives decision-making framework will be completed. 1.5 This guide does not suggest in what order the social, ecological, or economic attributes of sustainability should be evaluated or which one is most important. This is a decision of the company performing the decision-making evaluation.